Muscle weakness after administration of neuromuscular blocking agents: Do not immobilize the diaphragm unnecessarily

EFFECTS OF CHRONIC ADMINISTRATION OF TWO NEWLY SYNTHESIZED NONDEPOLARIZING NEUROMUSCULAR BLOCKING AGENTS

The potential changes In neuromuscular blockade after chronic (>24 h) administration of sub-paralytic doses of two newly introduced aminosteroidal muscle relaxants were investigated. Org-9426 (rocuronium) and Org-9487 were studied in the in vivo guinea pig gastrocnemius muscle-sciatic nerve preparation. The problems seen after prolonged administration of muscle relaxants are thought to ari...

The new neuromuscular blocking agents: do they offer any advantages?

The pharmacodynamics and pharmacokinetics of the two most recent aminosteroid neuromuscular blocking drugs to become available, rapacuronium bromide (Org 9487) and rocuronium bromide are reviewed. Two new classes of drug with neuromuscular blocking properties, the bis-tetrahydroisoquinolinium chlorofumarates and the tropinyl diester derivatives are introduced. Comparisons between these drugs an...

tracheal intubation without the use of neuromuscular blocking agents

Neuromuscular Blocking Agents

• Neuromuscular blocking agents are used to improve conditions for tracheal intubation, to provide immobility during surgery, and to facilitate mechanical ventilation. • The main site of action of neuromuscular blocking agents (muscle relaxants) is on the nicotinic cholinergic receptor at the endplate of muscle. They also have effects at presynaptic receptors located on the nerve terminal. • Su...

The Relative Sensitivities of Diaphragm and Other Muscles of the Guinea Pig to Neuromuscular Blocking Agents.

BUTLER 23 Enhancement of the Renal Excretion of Cesium-137 in Rats Treated with Acetazolamide and Related Compounds. B. V. RAMA SASTRY AND MILTON T. BUSH 30 Inhibition of the Renal Tubular Transport of Epinephrine by the Benzothiadiazine Compounds. BARBARA REN NICK, MARILYN PRYOR AND NORMA Yoss 42 Ainphotericin B Renal Toxicity in the Dog. WILLIAM T. BUTLER, GEORGE J. HILL II, CLARENCE F. SZWED...